MiRNA-mRNA integrated analysis reveals roles for miRNAs in primary breast tumors.

ABSTRACT:

Introduction

Few studies have performed expression profiling of both miRNA and mRNA from the same primary breast carcinomas. In this study we present and analyze data derived from expression profiling of 799 miRNAs in 101 primary human breast tumors, along with genome-wide mRNA profiles and extensive clinical information.

Methods

We investigate the relationship between these molecular components, in terms of their correlation with each other and with clinical characteristics. We use a systems biology approach to examine the correlative relationship between miRNA and mRNAs using statistical enrichment methods.

Results

We identify statistical significant differential expression of miRNAs between molecular intrinsic subtypes, and between samples with different levels of

SUBMITTER: Enerly E 

PROVIDER: S-EPMC3043070 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature