Identifying consensus disease pathways in Parkinson's disease using an integrative systems biology approach.

ABSTRACT: Parkinson's disease (PD) has had six genome-wide association studies (GWAS) conducted as well as several gene expression studies. However, only variants in MAPT and SNCA have been consistently replicated. To improve the utility of these approaches, we applied pathway analyses integrating both GWAS and gene expression. The top 5000 SNPs (p<0.01) from a joint analysis of three existing PD GWAS were identified and each assigned to a gene. For gene expression, rather than the traditional comparison of one anatomical region between sets of patients and controls, we identified differentially expressed genes between adjacent Braak regions in each individual and adjusted using average control expression profiles. Over-represented pathways were calculated using a hyper-geometric statistical compari

SUBMITTER: Edwards YJ 

PROVIDER: S-EPMC3043094 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature