Control of surface chemistry, substrate stiffness, and cell function in a novel terpolymer methacrylate library.

ABSTRACT: A focused library of methacrylate terpolymers was synthesized to explore the effects of varying surface chemistry and adhesive peptide ligands on cell function. The chemical diversity of methacrylate monomers enabled construction of a library of polymers in which one can systematically vary the chemical composition to achieve a wide range of contact angle, Young's modulus, and T(g) values. Furthermore, the materials were designed to allow surface immobilization of bioactive peptides. We then examined the effects of these material compositions on protein adsorption and cell attachment, proliferation, and differentiation. We observed that chemical composition of the polymers was an important determinant for NIH 3T3 cell attachment and proliferation, as well as human mesenchymal stem cell dif

SUBMITTER: Joy A 

PROVIDER: S-EPMC3043143 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature