Measuring retroactivity from noise in gene regulatory networks.

ABSTRACT: Synthetic gene regulatory networks show significant stochastic fluctuations in expression levels due to the low copy number of transcription factors. When a synthetic gene network is allowed to regulate a downstream network, the response time of the regulating transcription factors increases. This effect has been termed "retroactivity". In this article, we describe a method for estimating the retroactivity of a given system by measuring the stochastic noise in the transcription factor expression. We show that the noise in the output signal of the network can be affected significantly when the output is connected to a downstream module. More specifically, the output signal noise can show significantly longer correlations. We define retroactivity by the change in the correlation time. This m

SUBMITTER: Kim KH 

PROVIDER: S-EPMC3043224 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature