Vascularization of the dermal support enhances wound re-epithelialization by in situ delivery of epidermal keratinocytes.

ABSTRACT: Despite significant advances in management of severe wounds such as burns and chronic ulcers, autologous split-thickness skin grafts are still the gold standard of care. The main problems with this approach include pain and discomfort associated with harvesting autologous tissue, limited availability of donor sites, and the need for multiple surgeries. Although tissue engineering has great potential to provide alternative approaches for tissue regeneration, several problems have hampered progress in translating technological advances to clinical reality. Specifically, engineering of skin substitutes requires long culture times and delayed vascularization after implantation compromises graft survival. To address these issues we developed a novel two-prong strategy for tissue regeneration in

SUBMITTER: Lugo LM 

PROVIDER: S-EPMC3043980 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature