Coregulation of transcription factors and microRNAs in human transcriptional regulatory network.

ABSTRACT:

Background

MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression at the post-transcriptional level. Recent studies have suggested that miRNAs and transcription factors are primary metazoan gene regulators; however, the crosstalk between them still remains unclear.

Methods

We proposed a novel model utilizing functional annotation information to identify significant coregulation between transcriptional and post-transcriptional layers. Based on this model, function-enriched coregulation relationships were discovered and combined into different kinds of functional coregulation networks.

Results

We found that miRNAs may engage in a wider diversity of biological processes by coordinating with transcription factors, and this kind of cross-layer coregulatio

SUBMITTER: Chen CY 

PROVIDER: S-EPMC3044298 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature