Model for the regulation of Arabidopsis thaliana leaf margin development.

ABSTRACT: Biological shapes are often produced by the iterative generation of repeated units. The mechanistic basis of such iteration is an area of intense investigation. Leaf development in the model plant Arabidopsis is one such example where the repeated generation of leaf margin protrusions, termed serrations, is a key feature of final shape. However, the regulatory logic underlying this process is unclear. Here, we use a combination of developmental genetics and computational modeling to show that serration development is the morphological read-out of a spatially distributed regulatory mechanism, which creates interspersed activity peaks of the growth-promoting hormone auxin and the cup-shaped cotyledon2 (CUC2) transcription factor. This mechanism operates at the growing leaf margin via a regul

SUBMITTER: Bilsborough GD 

PROVIDER: S-EPMC3044365 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature