Gene clustering pattern, promoter architecture, and gene expression stability in eukaryotic genomes.

ABSTRACT: A balance between gene expression stability and evolvability is essential for the long-term maintenance of a living system. In this paper, we studied whether the genetic and epigenetic properties of the promoter affect gene expression variability. We hypothesized that upstream distance and orientation (head-to-head or head-to-tail) are important for the promoter architecture and gene expression variability. We found that in budding yeast genes with a short upstream distance tend to have low gene expression variability, and their promoter is flanked by strongly positioned nucleosomes and tends to have low nucleosome occupancy. These observations suggest that in vivo positioning of the flanking nucleosomes facilitates stable nucleosome depletion at the core promoter region and enhances gene

SUBMITTER: Woo YH 

PROVIDER: S-EPMC3044413 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature