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Specific biotinylation of IMP dehydrogenase.

ABSTRACT: IMP dehydrogenase (IMPDH) catalyzes a critical step in guanine nucleotide biosynthesis. IMPDH also has biological roles that are distinct from its enzymatic function. We report a biotin-linked reagent that selectively labels IMPDH and is released by dithiothreitol. This reagent will be invaluable in elucidating the moonlighting functions of IMPDH.

SUBMITTER: Hoefler BC 

PROVIDER: S-EPMC3044611 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Specific biotinylation of IMP dehydrogenase.

Hoefler B Christopher BC   Gollapalli Deviprasad R DR   Hedstrom Lizbeth L  

Bioorganic & medicinal chemistry letters 20110114 5

IMP dehydrogenase (IMPDH) catalyzes a critical step in guanine nucleotide biosynthesis. IMPDH also has biological roles that are distinct from its enzymatic function. We report a biotin-linked reagent that selectively labels IMPDH and is released by dithiothreitol. This reagent will be invaluable in elucidating the moonlighting functions of IMPDH. ...[more]

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