Bimodal distribution of RNA expression levels in human skeletal muscle tissue.

ABSTRACT:

Background

Many human diseases and phenotypes are related to RNA expression, levels of which are influenced by a wide spectrum of genetic and exposure-related factors. In a large genome-wide study of muscle tissue expression, we found that some genes exhibited a bimodal distribution of RNA expression, in contrast to what is usually assumed in studies of a single healthy tissue. As bimodality has classically been considered a hallmark of genetic control, we assessed the genome-wide prevalence, cause, and association of this phenomenon with diabetes-related phenotypes in skeletal muscle tissue from 225 healthy Pima Indians using exon array expression chips.

Results

Two independent batches of microarrays were used for bimodal assessment and comparison. Of the 17,881 genes analy

SUBMITTER: Mason CC 

PROVIDER: S-EPMC3044673 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature