Single-tissue and cross-tissue heritability of gene expression via identity-by-descent in related or unrelated individuals.

ABSTRACT: Family studies of individual tissues have shown that gene expression traits are genetically heritable. Here, we investigate cis and trans components of heritability both within and across tissues by applying variance-components methods to 722 Icelanders from family cohorts, using identity-by-descent (IBD) estimates from long-range phased genome-wide SNP data and gene expression measurements for approximately 19,000 genes in blood and adipose tissue. We estimate the proportion of gene expression heritability attributable to cis regulation as 37% in blood and 24% in adipose tissue. Our results indicate that the correlation in gene expression measurements across these tissues is primarily due to heritability at cis loci, whereas there is little sharing of trans regulation across tissues. One

SUBMITTER: Price AL 

PROVIDER: S-EPMC3044684 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature