A genome-wide study of DNA methylation patterns and gene expression levels in multiple human and chimpanzee tissues.

ABSTRACT: The modification of DNA by methylation is an important epigenetic mechanism that affects the spatial and temporal regulation of gene expression. Methylation patterns have been described in many contexts within and across a range of species. However, the extent to which changes in methylation might underlie inter-species differences in gene regulation, in particular between humans and other primates, has not yet been studied. To this end, we studied DNA methylation patterns in livers, hearts, and kidneys from multiple humans and chimpanzees, using tissue samples for which genome-wide gene expression data were also available. Using the multi-species gene expression and methylation data for 7,723 genes, we were able to study the role of promoter DNA methylation in the evolution of gene regula

SUBMITTER: Pai AA 

PROVIDER: S-EPMC3044686 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature