Genome-wide association study identifies Loci for body composition and structural soundness traits in pigs.

ABSTRACT:

Background

The recent completion of the swine genome sequencing project and development of a high density porcine SNP array has made genome-wide association (GWA) studies feasible in pigs.

Methodology/principal findings

Using Illumina's PorcineSNP60 BeadChip, we performed a pilot GWA study in 820 commercial female pigs phenotyped for backfat, loin muscle area, body conformation in addition to feet and leg (FL) structural soundness traits. A total of 51,385 SNPs were jointly fitted using Bayesian techniques as random effects in a mixture model that assumed a known large proportion (99.5%) of SNPs had zero effect. SNP annotations were implemented through the Sus scrofa Build 9 available from pig Ensembl. We discovered a number of candidate chromosomal regions, and some of them

SUBMITTER: Fan B 

PROVIDER: S-EPMC3044704 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature