Prioritization of epilepsy associated candidate genes by convergent analysis.

ABSTRACT:

Background

Epilepsy is a severe neurological disorder affecting a large number of individuals, yet the underlying genetic risk factors for epilepsy remain unclear. Recent studies have revealed several recurrent copy number variations (CNVs) that are more likely to be associated with epilepsy. The responsible gene(s) within these regions have yet to be definitively linked to the disorder, and the implications of their interactions are not fully understood. Identification of these genes may contribute to a better pathological understanding of epilepsy, and serve to implicate novel therapeutic targets for further research.

Methodology/principal findings

In this study, we examined genes within heterozygous deletion regions identified in a recent large-scale study, encompassing a

SUBMITTER: Jia P 

PROVIDER: S-EPMC3044734 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature