Protein complexes are central in the yeast genetic landscape.

ABSTRACT: If perturbing two genes together has a stronger or weaker effect than expected, they are said to genetically interact. Genetic interactions are important because they help map gene function, and functionally related genes have similar genetic interaction patterns. Mapping quantitative (positive and negative) genetic interactions on a global scale has recently become possible. This data clearly shows groups of genes connected by predominantly positive or negative interactions, termed monochromatic groups. These groups often correspond to functional modules, like biological processes or complexes, or connections between modules. However it is not yet known how these patterns globally relate to known functional modules. Here we systematically study the monochromatic nature of known biological

SUBMITTER: Michaut M 

PROVIDER: S-EPMC3044758 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature