Ontology highlight
ABSTRACT:
SUBMITTER: Joo HY
PROVIDER: S-EPMC3044976 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Joo Heui-Yun HY Jones Amada A Yang Chunying C Zhai Ling L Smith Archer D AD Zhang Zhuo Z Chandrasekharan Mahesh B MB Sun Zu-wen ZW Renfrow Matthew B MB Wang Yanming Y Chang Chenbei C Wang Hengbin H
The Journal of biological chemistry 20101223 9
Post-translational histone modifications play important roles in regulating gene expression programs, which in turn determine cell fate and lineage commitment during development. One such modification is histone ubiquitination, which primarily targets histone H2A and H2B. Although ubiquitination of H2A and H2B has been generally linked to gene silencing and gene activation, respectively, the functions of histone ubiquitination during eukaryote development are not well understood. Here, we identi ...[more]