Conceptual aspects of large meta-analyses with publicly available microarray data: a case study in oncology.

ABSTRACT: Large public repositories of microarray experiments offer an abundance of biological data. It is of interest to use and to combine the available material to create new biological information and to develop a broader view on biological phenomena.Meta-analyses recombine similar information over a series of experiments to sketch scientific aspects which were not accessible by each of the single experiments. Meta-analysis of high-throughput experiments has to handle methodological as well as technical challenges. Methodological aspects concern the identification of homogeneous material which can be combined by appropriate statistical procedures. Technical challenges come from the data management of large amounts of high-dimensional data, long computation time, as well as the handling of the st

SUBMITTER: Schmidberger M 

PROVIDER: S-EPMC3045047 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature