Different Functional Gene Clusters in Yeast have Different Spatial Distributions of the Transcription Factor Binding Sites.

ABSTRACT: Transcription factors control gene expression by binding to short specific DNA sequences, called transcription factor binding sites (TFBSs), in the promoter of a gene. Thus, studying the spatial distribution of TFBSs in the promoters may provide insights into the molecular mechanisms of gene regulation. I developed a method to construct the spatial distribution of TFBSs for any set of genes of interest. I found that different functional gene clusters have different spatial distributions of TFBSs, indicating that gene regulation mechanisms may be very different among different functional gene clusters. I also found that the binding sites for different transcription factors (TFs) may have different spatial distributions: a sharp peak, a plateau or no dominant single peak. The spatial distrib

SUBMITTER: Wu WS 

PROVIDER: S-EPMC3045049 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature