Factors affecting the accuracy of urine-based biomarkers of BSE.

ABSTRACT:

Background

Transmissible spongiform encephalopathy diseases are untreatable, uniformly fatal degenerative syndromes of the central nervous system that can be transmitted both within as well as between species. The bovine spongiform encephalopathy (BSE) epidemic and the emergence of a new human variant of Creutzfeldt-Jakob disease (vCJD), have profoundly influenced beef production processes as well as blood donation and surgical procedures. Simple, robust and cost effective diagnostic screening and surveillance tools are needed for both the preclinical and clinical stages of TSE disease in order to minimize both the economic costs and zoonotic risk of BSE and to further reduce the risk of secondary vCJD.

Objective

Urine is well suited as the matrix for an ante-mortem test for

SUBMITTER: Plews M 

PROVIDER: S-EPMC3045280 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature