Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolates.

ABSTRACT:

Background

M. catarrhalis is a gram-negative, gamma-proteobacterium and an opportunistic human pathogen associated with otitis media (OM) and exacerbations of chronic obstructive pulmonary disease (COPD). With direct and indirect costs for treating these conditions annually exceeding $33 billion in the United States alone, and nearly ubiquitous resistance to beta-lactam antibiotics among M. catarrhalis clinical isolates, a greater understanding of this pathogen's genome and its variability among isolates is needed.

Results

The genomic sequences of ten geographically and phenotypically diverse clinical isolates of M. catarrhalis were determined and analyzed together with two publicly available genomes. These twelve genomes were subjected to detailed comparative and predictive

SUBMITTER: Davie JJ 

PROVIDER: S-EPMC3045334 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature