Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial.

ABSTRACT:

Background

Bronchial thermoplasty (BT) is a bronchoscopic procedure that improves asthma control by reducing excess airway smooth muscle. Treated patients have been followed out to 5 years to evaluate long-term safety of this procedure.

Methods

Patients enrolled in the Asthma Intervention Research Trial were on inhaled corticosteroids ≥200 μg beclomethasone or equivalent + long-acting-beta2-agonists and demonstrated worsening of asthma on long-acting-β2-agonist withdrawal. Following initial evaluation at 1 year, subjects were invited to participate in a 4 year safety study. Adverse events (AEs) and spirometry data were used to assess long-term safety out to 5 years post-BT.

Results

45 of 52 treated and 24 of 49 control group subjects participated in long-term follow-u

SUBMITTER: Thomson NC 

PROVIDER: S-EPMC3045390 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature