Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences.

ABSTRACT:

Rationale

Human epidemiology and animal studies have convincingly shown the long-lasting impact of early life experiences on the development of individual differences in stress responsiveness in later life. The interplay between genes and environment underlies this phenomenon.

Objectives

We provide an overview of studies investigating the impact of early life experiences on the development of individual differences in neuroendocrine stress responsiveness in adulthood and address (1) impact of environment on later stress phenotypes, (2) role of genetic factors in modulating the outcome of environment, and (3) role of nonshared environmental experience in the outcome of gene × environment interplays. We present original findings where we investigated the influence of nonshared

SUBMITTER: Claessens SE 

PROVIDER: S-EPMC3045508 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature