Multiple kinases and system robustness: a link between Cdc37 and genome integrity.

ABSTRACT: We identified 38 genes as having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37, using a genome-wide synthetic screening approach. The identified genes included a sub-network of highly interacting genes enriched for functions in genome integrity and comprising multiple components of several discrete molecular machines. A network analysis approach related these machines to a small group of cell cycle checkpoint kinases.

SUBMITTER: Caplan AJ 

PROVIDER: S-EPMC3045565 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature