A catalytic, asymmetric formal synthesis of (+)-hamigeran B.

ABSTRACT: A concise asymmetric, formal synthesis of (+)-hamigeran B is reported. A Pd-catalyzed, decarboxylative allylic alkylation, employing a trifluoromethylated derivative of t-BuPHOX, is utilized as the enantioselective step to form the critical quaternary carbon center in excellent yield and enantioselectivity. The product is converted in three steps to a late-stage intermediate previously used in the synthesis of hamigeran B.

SUBMITTER: Mukherjee H 

PROVIDER: S-EPMC3045637 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature