Calcium plus vitamin D supplementation and the risk of incident diabetes in the Women's Health Initiative.

ABSTRACT:

Objective

Experimental and epidemiologic studies suggest that calcium and vitamin D may reduce the risk of developing diabetes. We examined the effect of calcium plus vitamin D supplementation on the incidence of drug-treated diabetes in postmenopausal women.

Research design and methods

The Women's Health Initiative Calcium/Vitamin D Trial randomly assigned postmenopausal women to receive 1,000 mg elemental calcium plus 400 IU of vitamin D3 daily, or placebo, in a double-blind fashion. Among 33,951 participants without self-reported diabetes at baseline, we ascertained by treatment assignment new diagnoses of diabetes treated with oral hypoglycemic agents or insulin. Effects of the intervention on fasting measurements of glucose, insulin, and insulin resistance were examined

SUBMITTER: de Boer IH 

PROVIDER: S-EPMC3046029 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature