Insights from molecular modeling and dynamics simulation of pathogen resistance (R) protein from brinjal.

ABSTRACT: Resistance (R) protein recognizes molecular signature of pathogen infection and activates downstream hypersensitive response signalling in plants. R protein works as a molecular switch for pathogen defence signalling and represent one of the largest plant gene family. Hence, understanding molecular structure and function of R proteins has been of paramount importance for plant biologists. The present study is aimed at predicting structure of R proteins signalling domains (CC-NBS) by creating a homology model, refining and optimising the model by molecular dynamics simulation and comparing ADP and ATP binding. Based on sequence similarity with proteins of known structures, CC-NBS domains were initially modelled using CED- 4 (cell death abnormality protein) and APAF-1 (apoptotic protease act

SUBMITTER: Shrivastava D 

PROVIDER: S-EPMC3046036 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature