MicroRNA expression analysis: clinical advantage of propranolol reveals key microRNAs in myocardial infarction.

ABSTRACT:

Background

As playing important roles in gene regulation, microRNAs (miRNAs) are believed as indispensable involvers in the pathogenesis of myocardial infarction (MI) that causes significant morbidity and mortality. Working on a hypothesis that modulation of only some key members in the miRNA superfamily could benefit ischemic heart, we proposed a microarray based network biology approach to identify them with the recognized clinical effect of propranolol as a prompt.

Methods

A long-term MI model of rat was established in this study. The microarray technology was applied to determine the global miRNA expression change intervened by propranolol. Multiple network analyses were sequentially applied to evaluate the regulatory capacity, efficiency and emphasis of the miRNAs which

SUBMITTER: Zhu W 

PROVIDER: S-EPMC3046111 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature