Regulation of retinoid receptors by retinoic acid and axonal contact in Schwann cells.

ABSTRACT:

Background

Schwann cells (SCs) are the cell type responsible for the formation of the myelin sheath in the peripheral nervous system (PNS). As retinoic acid (RA) and other retinoids have a profound effect as regulators of the myelination program, we sought to investigate how their nuclear receptors levels were regulated in this cell type.

Methodology/principal findings

In the present study, by using Schwann cells primary cultures from neonatal Wistar rat pups, as well as myelinating cocultures of Schwann cells with embryonic rat dorsal root ganglion sensory neurons, we have found that sustained expression of RXR-γ depends on the continuous presence of a labile activator, while axonal contact mimickers produced an increase in RXR-γ mRNA and protein levels, increment that coul

SUBMITTER: Latasa MJ 

PROVIDER: S-EPMC3046125 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature