New implications on genomic adaptation derived from the Helicobacter pylori genome comparison.

ABSTRACT:

Background

Helicobacter pylori has a reduced genome and lives in a tough environment for long-term persistence. It evolved with its particular characteristics for biological adaptation. Because several H. pylori genome sequences are available, comparative analysis could help to better understand genomic adaptation of this particular bacterium.

Principal findings

We analyzed nine H. pylori genomes with emphasis on microevolution from a different perspective. Inversion was an important factor to shape the genome structure. Illegitimate recombination not only led to genomic inversion but also inverted fragment duplication, both of which contributed to the creation of new genes and gene family, and further, homological recombination contributed to events of inversion. Based on t

SUBMITTER: Lara-Ramirez EE 

PROVIDER: S-EPMC3046158 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature