Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.

ABSTRACT: Increased values of multiple adiposity-related anthropometric traits are important risk factors for many common complex diseases. We performed a genome-wide association (GWA) study for four quantitative traits related to body size and adiposity (BMI, weight, waist circumference, and height) in a cohort of 1,792 adult Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS). This is the first GWA study of anthropometric traits in Filipinos, a population experiencing a rapid transition into a more obesogenic environment. In addition to identifying suggestive evidence of additional single-nucleotide polymorphism (SNP) association signals (P < 10(-5)), we replicated (P < 0.05, same direction of additive effect) associations previously reported in European populations of bo

SUBMITTER: Croteau-Chonka DC 

PROVIDER: S-EPMC3046220 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature