A novel BDNF polymorphism affects plasma protein levels in interaction with early adversity in rhesus macaques.

ABSTRACT: Early stressful events can increase vulnerability for psychopathology, although knowledge on the effectors is still limited. In this report we describe the characterization of a single nucleotide polymorphism (SNP) in rhesus macaques, which results in a Val to Met transition in the pro-BDNF domain, similar to a well described variant in the human gene. Further, we tested the hypothesis that peripheral levels of BDNF, which is involved in the response to stress and in the pathophysiology of anxiety and depression, might be differentially affected in a non-human primate model of early adverse rearing in a genotype-dependent manner. Males and females rhesus macaques reared either with their mothers (MR), in peer-only groups (PR), or in a "surrogate/peer-reared" (SPR) condition with limited pe

SUBMITTER: Cirulli F 

PROVIDER: S-EPMC3046296 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature