Large scale comparison of global gene expression patterns in human and mouse.

ABSTRACT:

Background

It is widely accepted that orthologous genes between species are conserved at the sequence level and perform similar functions in different organisms. However, the level of conservation of gene expression patterns of the orthologous genes in different species has been unclear. To address the issue, we compared gene expression of orthologous genes based on 2,557 human and 1,267 mouse samples with high quality gene expression data, selected from experiments stored in the public microarray repository ArrayExpress.

Results

In a principal component analysis (PCA) of combined data from human and mouse samples merged on orthologous probesets, samples largely form distinctive clusters based on their tissue sources when projected onto the top principal components. The most

SUBMITTER: Zheng-Bradley X 

PROVIDER: S-EPMC3046484 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature