Novel genes exhibit distinct patterns of function acquisition and network integration.

ABSTRACT:

Background

Genes are created by a variety of evolutionary processes, some of which generate duplicate copies of an entire gene, while others rearrange pre-existing genetic elements or co-opt previously non-coding sequence to create genes with 'novel' sequences. These novel genes are thought to contribute to distinct phenotypes that distinguish organisms. The creation, evolution, and function of duplicated genes are well-studied; however, the genesis and early evolution of novel genes are not well-characterized. We developed a computational approach to investigate these issues by integrating genome-wide comparative phylogenetic analysis with functional and interaction data derived from small-scale and high-throughput experiments.

Results

We examine the function and evolution

SUBMITTER: Capra JA 

PROVIDER: S-EPMC3046487 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature