Genetic influences on serum bilirubin in American Indians: The Strong Heart Family Study.

ABSTRACT:

Objective

To identify genetic variation influencing serum bilirubin levels in American Indians, we performed genome-wide screening and association analyses in the Strong Heart Family Study. Bilirubin is an endogenous antioxidant that has demonstrated an inverse relationship with cardiovascular disease. Genetic variation within the promoter region of uridine diphosphate glucuronosyltransferase (UGT1A1) on chromosome 2q has been associated with elevated serum bilirubin levels in European populations. However, no study has investigated the UGT1A1 promoter in American Indians.

Methods

Statistical analyses were carried out with 3,484 participants aged 14 to 93 years recruited from three geographic areas in the United States; Arizona, Oklahoma, and North and South Dakota.

Resul

SUBMITTER: Melton PE 

PROVIDER: S-EPMC3046552 | biostudies-literature | 2011 Jan-Feb

REPOSITORIES: biostudies-literature