Identification of metabolic modifiers that underlie phenotypic variations in energy-balance regulation.

ABSTRACT:

Objective

Although recent studies have shown that human genomes contain hundreds of loci that exhibit signatures of positive selection, variants that are associated with adaptation in energy-balance regulation remain elusive. We reasoned that the difficulty in identifying such variants could be due to heterogeneity in selection pressure and that an integrative approach that incorporated experiment-based evidence and population genetics-based statistical judgments would be needed to reveal important metabolic modifiers in humans.

Research design and methods

To identify common metabolic modifiers that underlie phenotypic variation in diabetes-associated or obesity-associated traits in humans, or both, we screened 207 candidate loci for regulatory single nucleotide polymorphism

SUBMITTER: Chang CL 

PROVIDER: S-EPMC3046833 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature