Relationship between sun exposure and melanoma risk for tumours in different body sites in a large case-control study in a temperate climate.

ABSTRACT:

Aim

A melanoma case-control study was conducted to elucidate the complex relationship between sun exposure and risk.

Methods

Nine hundred and sixty population-ascertained cases, 513 population and 174 sibling controls recruited in England provided detailed sun exposure and phenotype data; a subset provided serum 25-hydroxyvitamin D(2)+D(3) levels.

Results

Phenotypes associated with a tendency to sunburn and reported sunburn at ≥ 20 years of age were associated with increased melanoma risk (odds ratio (OR) 1.56, 95% confidence intervals (CI) 1.23-1.99). Holiday sun exposure was not associated with an increased melanoma risk although this may be in part because reported sun exposure overall was much lower in those with a sun-sensitive phenotype, particularly among contr

SUBMITTER: Newton-Bishop JA 

PROVIDER: S-EPMC3046902 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature