Lorcaserin, a 5-HT(2C) receptor agonist, reduces body weight by decreasing energy intake without influencing energy expenditure.

ABSTRACT:

Context

Lorcaserin, a selective 5-hydroxytryptamine (5-HT)(2C) receptor agonist, reduces body weight. It is unclear whether weight loss is due to reduced energy intake (EI) or also to enhanced energy expenditure (EE).

Objective

This study tested the effect of lorcaserin on EI and EE.

Design, participants, and intervention

In a double-blind, randomized, placebo-controlled trial, 57 (39 women) overweight and obese (body mass index, 27-45 kg/m(2)) adults were randomized to placebo (n = 28) or 10 mg twice daily lorcaserin (n = 29) for 56 d. Weight maintenance was imposed during d 1-7. Beginning on d 8, participants followed a diet and exercise plan targeting a 600 kcal/d deficit.

Outcomes

At baseline and after 7 and 56 d of treatment, we measured body weight, body

SUBMITTER: Martin CK 

PROVIDER: S-EPMC3047218 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature