Rapid suppression of growth hormone concentration by overeating: potential mediation by hyperinsulinemia.

ABSTRACT:

Context

The very low GH concentration in obesity is commonly attributed to high body fat mass; however, the influence of overeating on GH secretion is not clear.

Objective

The aim of the study was to examine the effects of 2 wk of overeating on changes in GH secretion.

Setting

Subjects were admitted to the hospital and stayed within the Michigan Clinical Research Unit throughout the entire 2-wk overeating period.

Participants

We studied seven healthy, nonobese men (body mass index, 24 ± 1 kg/m(2); age, 25 ± 1 yr).

Intervention

Subjects ate standardized meals containing 70 kcal/kg fat free mass/d (∼4000 kcal/d) for 2 wk.

Main outcome measures

Twenty-four-hour plasma concentrations of GH (every 20 min) and insulin (every 2 h) were measured before ov

SUBMITTER: Cornford AS 

PROVIDER: S-EPMC3047219 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature