A dual sugar challenge test for lipogenic sensitivity to dietary fructose.

ABSTRACT:

Context

Increased hepatic de novo lipogenesis (DNL) in response to dietary sugar is implicated in dyslipidemia, fatty liver, and insulin resistance.

Objective

The aim of the study was to develop a simple outpatient tolerance test for lipogenic sensitivity to dietary sugar.

Design and setting

In inpatients given repeated doses of fructose, protocol 1 compared the acute increase in DNL determined from the percentage of palmitate ("new palmitate") and the percentage of isotopically labeled palmitate ("%DNL") in very low-density lipoprotein triglyceride (TG). Protocol 2 compared the increase in new palmitate in outpatients given three different sugar beverages in a randomized crossover design.

Participants

There were 15 lean and overweight volunteers in protocol 1

SUBMITTER: Hudgins LC 

PROVIDER: S-EPMC3047222 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature