Airway hyperresponsiveness in children with sickle cell anemia.

ABSTRACT:

Background

The high prevalence of airway hyperresponsiveness (AHR) among children with sickle cell anemia (SCA) remains unexplained.

Methods

To determine the relationship between AHR, features of asthma, and clinical characteristics of SCA, we conducted a multicenter, prospective cohort study of children with SCA. Dose response slope (DRS) was calculated to describe methacholine responsiveness, because 30% of participants did not achieve a 20% decrease in FEV1 after inhalation of the highest methacholine concentration, 25 mg/mL. Multiple linear regression analysis was done to identify independent predictors of DRS.

Results

Methacholine challenge was performed in 99 children with SCA aged 5.6 to 19.9 years (median, 12.8 years). Fifty-four (55%) children had a provocati

SUBMITTER: Field JJ 

PROVIDER: S-EPMC3047289 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature