Comparative tissue transcriptomics reveal prompt inter-organ communication in response to local bacterial kidney infection.

ABSTRACT:

Background

Mucosal infections elicit inflammatory responses via regulated signaling pathways. Infection outcome depends strongly on early events occurring immediately when bacteria start interacting with cells in the mucosal membrane. Hitherto reported transcription profiles on host-pathogen interactions are strongly biased towards in vitro studies. To detail the local in vivo genetic response to infection, we here profiled host gene expression in a recent experimental model that assures high spatial and temporal control of uropathogenic Escherichia coli (UPEC) infection within the kidney of a live rat.

Results

Transcriptional profiling of tissue biopsies from UPEC-infected kidney tissue revealed 59 differentially expressed genes 8 h post-infection. Their relevance for the i

SUBMITTER: Boekel J 

PROVIDER: S-EPMC3047304 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature