Myocardial parvovirus B19 persistence: lack of association with clinicopathologic phenotype in adults with heart failure.

ABSTRACT:

Background

Multiple viruses have been isolated from the heart, but their significance remains controversial. We sought to determine the prevalence of cardiotropic viruses in endomyocardial biopsy (EMB) samples from adult patients with heart failure (HF) and to define the clinicopathologic profile of patients exhibiting viral positivity.

Methods and results

EMB from 100 patients (median ejection fraction, 30%; interquartile range [IQR], 20% to 45%) presenting for cardiomyopathy evaluation (median symptom duration, 5 months; IQR, 1 to 13 months) were analyzed by polymerase chain reaction for adenovirus, cytomegalovirus, enteroviruses, Epstein-Barr virus, and parvovirus B19. Each isolate was sequenced, and viral load was determined. Parvovirus B19 was the only virus detected in

SUBMITTER: Stewart GC 

PROVIDER: S-EPMC3047418 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature