A novel method of characterizing genetic sequences: genome space with biological distance and applications.

ABSTRACT:

Background

Most existing methods for phylogenetic analysis involve developing an evolutionary model and then using some type of computational algorithm to perform multiple sequence alignment. There are two problems with this approach: (1) different evolutionary models can lead to different results, and (2) the computation time required for multiple alignments makes it impossible to analyse the phylogeny of a whole genome. This motivates us to create a new approach to characterize genetic sequences.

Methodology

To each DNA sequence, we associate a natural vector based on the distributions of nucleotides. This produces a one-to-one correspondence between the DNA sequence and its natural vector. We define the distance between two DNA sequences to be the distance between their a

SUBMITTER: Deng M 

PROVIDER: S-EPMC3047556 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature