A conserved G₁ regulatory circuit promotes asynchronous behavior of nuclei sharing a common cytoplasm.

ABSTRACT: Synthesis and accumulation of conserved cell cycle regulators such as cyclins are thought to promote G₁/S and G₂/M transitions in most eukaryotes. When cells at different stages of the cell cycle are fused to form heterokaryons, the shared complement of regulators in the cytoplasm induces the nuclei to become synchronized. However, multinucleate fungi often display asynchronous nuclear division cycles, even though the nuclei inhabit a shared cytoplasm. Similarly, checkpoints can induce nuclear asynchrony in multinucleate cells by arresting only the nucleus that receives damage. The cell biological basis for nuclear autonomy in a common cytoplasm is not known. Here we show that in the filamentous fungus Ashbya gossypii, sister nuclei born from one mitosis immediately lose synchrony in the s

SUBMITTER: Nair DR 

PROVIDER: S-EPMC3047801 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature