Ontology highlight
ABSTRACT:
SUBMITTER: Pelletier C
PROVIDER: S-EPMC3048078 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Pelletier Cory C Speed William C WC Paranjape Trupti T Keane Katie K Blitzblau Rachel R Hollestelle Antoinette A Safavi Kyan K van den Ouweland Ans A Zelterman Daniel D Slack Frank J FJ Kidd Kenneth K KK Weidhaas Joanne B JB
Cell cycle (Georgetown, Tex.) 20110101 1
Genetic markers identifying women at an increased risk of developing breast cancer exist, yet the majority of inherited risk remains elusive. While numerous BRCA1 coding sequence mutations are associated with breast cancer risk, BRCA1 mutations account for less then 5% of breast cancer risk. Since 3' untranslated region (3'UTR) polymorphisms disrupting microRNA (miRNA) binding can be functional and can act as genetic markers of cancer risk, we tested the hypothesis that such polymorphisms in the ...[more]