Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast.

ABSTRACT: Reduced fecundity has been associated with some alleles that enhance longevity in invertebrate and mammalian models. This observation has been suggested to support the antagonistic pleiotropy theory of aging, which predicts that alleles of some genes promoting fitness early in life have detrimental effects later in life that limit survival. In only a few cases, however, has the relative fitness of long-lived mutants been quantified through direct competition with the wild type genotype. Here we report the first comprehensive analysis of longevity/fitness trade-offs by measuring the relative fitness of 49 long-lived yeast variants in a direct competition assay with wild type cells. We find that 32 (65%) of these variants show a significant defect in fitness in this competition assay. In 26

SUBMITTER: Delaney JR 

PROVIDER: S-EPMC3048082 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature