Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women.

ABSTRACT:

Objectives

The objective of the study was to evaluate whether serum concentrations of metabolic intermediates are related to adiposity and insulin sensitivity (Si) in overweight healthy subjects and compare changes in metabolic intermediates with similar weight loss achieved by diet only or diet plus exercise.

Design

This was a randomized controlled trial.

Participants and intervention

The cross-sectional study included 46 (aged 36.8 ± 1.0 yr) overweight (body mass index 27.8 ± 0.7 kg/m(2)) subjects enrolled in a 6-month study of calorie restriction. To determine the effect of diet only or diet plus exercise on metabolic intermediates, 35 subjects were randomized to control (energy intake at 100% of energy requirements); CR (25% calorie restriction), or CR+EX: (12.5%

SUBMITTER: Redman LM 

PROVIDER: S-EPMC3048325 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature