Treatment of obstructive sleep apnea improves cardiometabolic function in young obese women with polycystic ovary syndrome.

ABSTRACT:

Context

Women with polycystic ovary syndrome (PCOS) are insulin resistant and have a high risk of early-onset diabetes and cardiovascular disease. Obstructive sleep apnea (OSA) has adverse cardiometabolic consequences and is highly prevalent in women with PCOS. We sought to determine whether continuous positive airway pressure (CPAP) treatment of OSA has beneficial effects on cardiometabolic function in PCOS.

Methods

Laboratory polysomnography and cardiometabolic measurements including insulin sensitivity and secretion (iv glucose tolerance test); 24-h profiles of plasma catecholamines, cortisol, and leptin; and daytime profiles of blood pressure and cardiac autonomic activity (heart rate variability) were obtained at baseline and again after 8 wk of home CPAP treatment with

SUBMITTER: Tasali E 

PROVIDER: S-EPMC3048326 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature