Diverse roles and interactions of the SWI/SNF chromatin remodeling complex revealed using global approaches.

ABSTRACT: A systems understanding of nuclear organization and events is critical for determining how cells divide, differentiate, and respond to stimuli and for identifying the causes of diseases. Chromatin remodeling complexes such as SWI/SNF have been implicated in a wide variety of cellular processes including gene expression, nuclear organization, centromere function, and chromosomal stability, and mutations in SWI/SNF components have been linked to several types of cancer. To better understand the biological processes in which chromatin remodeling proteins participate, we globally mapped binding regions for several components of the SWI/SNF complex throughout the human genome using ChIP-Seq. SWI/SNF components were found to lie near regulatory elements integral to transcription (e.g. 5' ends, R

SUBMITTER: Euskirchen GM 

PROVIDER: S-EPMC3048368 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature