Identifying causal genes and dysregulated pathways in complex diseases.

ABSTRACT: In complex diseases, various combinations of genomic perturbations often lead to the same phenotype. On a molecular level, combinations of genomic perturbations are assumed to dys-regulate the same cellular pathways. Such a pathway-centric perspective is fundamental to understanding the mechanisms of complex diseases and the identification of potential drug targets. In order to provide an integrated perspective on complex disease mechanisms, we developed a novel computational method to simultaneously identify causal genes and dys-regulated pathways. First, we identified a representative set of genes that are differentially expressed in cancer compared to non-tumor control cases. Assuming that disease-associated gene expression changes are caused by genomic alterations, we determined potent

SUBMITTER: Kim YA 

PROVIDER: S-EPMC3048384 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature